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KMID : 0370219970410010018
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Yakhak Hoeji
1997 Volume.41 No. 1 p.18 ~ p.21
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Synthesis of Azabicyclo[3.2.1]octane Skeleton of Tropane Alkaloid
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서영거/Suh YG
최영기/정재경/민경훈/Choi YG/Jung JK/Min KH
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Abstract
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Synthesis of an optically active azabicyclo[3.2.1]octane skeleton as a backbone of the tropane alkaloids has been achieved by employing intramolecular Mannich reaction. Utilization of (R)-alpha-methylbenzylamine as a chiral auxiliary provided an excellent cyclization of amino dioxolane precursor. However, this auxiliary did not afford high asymmertic induction for the preparation of the optically active cyclization precursor.
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